{"id":17345,"date":"2024-08-08T11:24:59","date_gmt":"2024-08-08T08:24:59","guid":{"rendered":"https:\/\/dementsus.ee\/?p=17345"},"modified":"2024-08-08T11:38:49","modified_gmt":"2024-08-08T08:38:49","slug":"alzheimeri-tove-seos-unehairetega","status":"publish","type":"post","link":"https:\/\/dementsus.ee\/en\/alzheimeri-tove-seos-unehairetega\/","title":{"rendered":"Alzheimeri t\u00f5ve seos uneh\u00e4iretega"},"content":{"rendered":"
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Foto: freepik.com<\/figcaption><\/figure>\n

Kokkuv\u00f5te artiklist \u201eThe Link Between Alzheimer\u2019s and Sleep<\/em>\u201c (Alzheimeri t\u00f5ve seos uneh\u00e4iretega). Artikli autor on kliiniline ps\u00fchholoog, unemeditsiini ekspert Michael Breus, PhD.<\/p>\n

Artikkel avaldatud 30.04.2024. https:\/\/sleepdoctor.com\/physical-health\/alzheimers-and-sleep\/<\/a><\/p>\n

Kokkuv\u00f5tte koostaja Karin Lilienberg<\/p>\n

<\/h3>\n

<\/h3>\n

Alzheimeri t\u00f5ve seos uneh\u00e4iretega<\/strong><\/h3>\n

Alzheimeri t\u00f5vega (AT) inimestel on sageli uneh\u00e4ired. M\u00f5ned uuringud n\u00e4itavad, et muutused unemustrites, nt. s\u00fcgavas unes viibimise aja l\u00fchenemine, unetus ja obstruktiivne uneapnoe v\u00f5ivad p\u00f5hjustada muutusi ajukeemias ning suurendada Alzheimeri t\u00f5ve tekke t\u00f5en\u00e4osust.<\/p>\n

Ka normaalse vananemise korral v\u00f5ib uinumine v\u00f5tta kauem aega, sageneb \u00f6ine \u00e4rkamine ja norskamine, suureneb p\u00e4evauinaku soov. Aga AT korral on uneprobleemide esinemissagedus ja m\u00f5ju elukvaliteedile suurem. Uneh\u00e4ired ilmnevad sageli haiguse varajases staadiumis ning \u00a0s\u00fcvenevad AT progresseerumisel.<\/p>\n

Alzheimeri t\u00f5be p\u00f5devatel inimestel on sageli h\u00e4iritud \u00f6\u00f6p\u00e4evar\u00fctm<\/strong> – nad on \u00f6\u00f6sel aktiivsemad ja p\u00e4eval v\u00f5ivad palju magada. Nad kogevad rohkem ka ebaregulaarseid une-\u00e4rkveloleku r\u00fctme: magavad mitu korda p\u00e4evas ja l\u00fchemaid perioode, mitte \u00fcks pikem uneperiood \u00f6\u00f6sel.<\/p>\n

Ekspertide s\u00f5nul v\u00f5ivad need Alzheimeri t\u00f5ve muutused olla tingitud igap\u00e4evaseid kehar\u00fctme kontrolliva ajustruktuuri suprahiasmaatiline tuum<\/em> degeneratsioonist. Samuti on t\u00e4heldatud, et AT-ga inimestel on madalam unisust esile kutsuva hormooni melatoniini tase. \u00d6\u00f6p\u00e4evar\u00fctmi segavad ka valguse tajumise h\u00e4ired vananemisega seotud n\u00e4gemisprobleemid korral.<\/p>\n

AT-ga isikutel on h\u00e4iritud unere\u017eiim. <\/strong>S\u00fcgava unefaasi (REM-uni) pikkus l\u00fcheneb, mist\u00f5ttu v\u00e4heneb aeg, mis kulub aju kahjulikest valkudest puhastamisele. REM-une kadumine v\u00f5ib m\u00f5jutada m\u00e4lu ja kiiret aju degeneratsiooni. Lisaks v\u00f5ib AT-ga inimestel olla uni killustatud, st. nad \u00e4rkavad sagedamini. On ka v\u00f5imalus, et k\u00f5rgenenud beeta-am\u00fcloidi tase p\u00f5hjustab une killustumist ja muid uneh\u00e4ireid.<\/p>\n

REM-une faasi iseloomustab silmade kiire liikumine ja unen\u00e4gude n\u00e4gemine, aga lihased sellel ajal ei liigu. REM-une k\u00e4itumish\u00e4ire<\/strong> korral r\u00e4\u00e4givad ja liiguvad inimesed REM-unes ringi, elades f\u00fc\u00fcsiliselt l\u00e4bi unen\u00e4gu. REM-une k\u00e4itumish\u00e4ire on tugevamalt seotud teiste n\u00e4rvis\u00fcsteemi degeneratiivsete haigustega, nagu Parkinsoni t\u00f5ve v\u00f5i Lewy kehakeste dementsusega.<\/p>\n

Uuringud n\u00e4itavad, et 40\u201370% AT-ga inimestel esineb hingamisprobleem obstruktiivne uneapnoe <\/strong>(OA) ja dementsuse raskusaste v\u00f5ib olla seotud hingamisprobleemide t\u00f5sidusega. AT-ga inimestel on viis korda suurem t\u00f5en\u00e4osus haigestuda OA-sse. Obstruktiivne uneapnoe v\u00f5ib s\u00fcvendada p\u00e4evaseid AD s\u00fcmptomeid, nagu t\u00e4helepanu- ja m\u00e4luprobleemid.<\/p>\n

Dementsusega inimesed kogevad sageli n\u00e4htust, mida nimetatakse “p\u00e4ikeseloojangu s\u00fcndroomiks<\/strong>“. Seda iseloomustab rahutuse, segaduse ja \u00e4rrituvuse suurenemine \u00f5htul, kui p\u00e4ike loojub. See s\u00fcndroom esineb eriti dementsusega inimestel, kellel on h\u00e4iritud une-\u00e4rkveloleku ts\u00fckkel. Teadlaste s\u00f5nul v\u00f5ib p\u00f5hjuseks olla \u00f6\u00f6p\u00e4evar\u00fctmi ja une-\u00e4rkveloleku ts\u00fcklit kontrolliva ajuosa \u201esuprahiasmaatiline tuum\u201c kahjustus.<\/p>\n

Une parandamise mittefarmakoloogilised strateegiatena <\/strong>soovitatakse<\/p>\n

    \n
  1. Parandada unekeskkonda:\u00a0 \u00a0hoida magamiskoht \u00f6\u00f6sel pimedas ja p\u00e4eval eredalt valgustatud. Valgus on k\u00f5ige olulisem, et hoida inimeste igap\u00e4evast une-\u00e4rkveloleku ts\u00fcklit \u00f5igel teel.<\/li>\n
  2. K\u00f5rvaldada m\u00fcra ja h\u00e4irivad tegurid: hoida magamisruum vaikne. V\u00e4ltida v\u00f5i piirata AT-ga inimese \u00e4ratamist \u00f6\u00f6sel meditsiinilistel p\u00f5hjustel, n\u00e4iteks ravimite andmiseks v\u00f5i anal\u00fc\u00fcside v\u00f5tmiseks.<\/li>\n
  3. Harjutada head uneh\u00fcgieeni: j\u00e4rgida regulaarset magamamineku ja \u00e4rkamisaega, piirata kofeiini tarbimist, treenida p\u00e4evasel ajal ja v\u00e4ltida suuri s\u00f6\u00f6gikordi \u00f5htusel ajal.<\/li>\n
  4. Piirata uinakuid: \u00f6ist und saab hooldaja parandada, piirates hooldatava p\u00e4evaseid uinakuid, eriti p\u00e4rast kella 15.00. Kuigi liigne p\u00e4evane unisus on AT-ga inimestel tavaline, v\u00f5ib liigne hiline uinak h\u00e4irida \u00f6\u00f6sel magama j\u00e4\u00e4mist.<\/li>\n<\/ol>\n

     <\/p>\n

    Kasutatud artiklid:<\/strong><\/p>\n

      \n
    1. Sadeghmousavi S. et al<\/em>. (2020). The effect of insomnia on development of Alzheimer’s disease. J Neuroinflammation. 2020 Oct 6;17(1):289. doi: 10.1186\/s12974-020-01960-9.<\/li>\n
    2. Omonigho M. B. et al.<\/em> (2020). Obstructive sleep apnea, cognition and Alzheimer’s disease: A systematic review integrating three decades of multidisciplinary research. Sleep Med Rev. 2020 Apr:50:101250. doi: 10.1016\/j.smrv.2019.101250. Epub 2019 Dec 12.<\/li>\n
    3. Reddy O.C. et al.<\/em> (2020). The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices. Brain Sci. 2020 Nov 17;10(11):868. doi: 10.3390\/brainsci10110868.<\/li>\n
    4. Sharma A. et al<\/em>. (2021). Circadian Rhythm Disruption and Alzheimer’s Disease: The Dynamics of a Vicious Cycle. Curr Neuropharmacol. 2021;19(2):248-264. doi: 10.2174\/1570159X18666200429013041.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      Kokkuv\u00f5te artiklist \u201eThe Link Between Alzheimer\u2019s and Sleep\u201c (Alzheimeri t\u00f5ve seos uneh\u00e4iretega). Artikli autor on kliiniline ps\u00fchholoog, unemeditsiini ekspert Michael Breus, PhD. Artikkel avaldatud 30.04.2024. https:\/\/sleepdoctor.com\/physical-health\/alzheimers-and-sleep\/ Kokkuv\u00f5tte koostaja Karin Lilienberg Alzheimeri t\u00f5ve seos uneh\u00e4iretega Alzheimeri t\u00f5vega (AT) inimestel on sageli uneh\u00e4ired. M\u00f5ned uuringud n\u00e4itavad, et muutused unemustrites, nt. s\u00fcgavas unes viibimise aja l\u00fchenemine, unetus ja […]<\/p>\n","protected":false},"author":15,"featured_media":17346,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"autor":[31],"class_list":["post-17345","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-maaratlemata","autor-ragne-heiste"],"yoast_head":"\nAlzheimeri t\u00f5ve seos uneh\u00e4iretega - Dementsuse Kompetentsikeskus<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dementsus.ee\/en\/alzheimeri-tove-seos-unehairetega\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimeri t\u00f5ve seos uneh\u00e4iretega - Dementsuse Kompetentsikeskus\" \/>\n<meta property=\"og:description\" content=\"Kokkuv\u00f5te artiklist \u201eThe Link Between Alzheimer\u2019s and Sleep\u201c (Alzheimeri t\u00f5ve seos uneh\u00e4iretega). Artikli autor on kliiniline ps\u00fchholoog, unemeditsiini ekspert Michael Breus, PhD. Artikkel avaldatud 30.04.2024. https:\/\/sleepdoctor.com\/physical-health\/alzheimers-and-sleep\/ Kokkuv\u00f5tte koostaja Karin Lilienberg Alzheimeri t\u00f5ve seos uneh\u00e4iretega Alzheimeri t\u00f5vega (AT) inimestel on sageli uneh\u00e4ired. 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Artikli autor on kliiniline ps\u00fchholoog, unemeditsiini ekspert Michael Breus, PhD. Artikkel avaldatud 30.04.2024. https:\/\/sleepdoctor.com\/physical-health\/alzheimers-and-sleep\/ Kokkuv\u00f5tte koostaja Karin Lilienberg Alzheimeri t\u00f5ve seos uneh\u00e4iretega Alzheimeri t\u00f5vega (AT) inimestel on sageli uneh\u00e4ired. 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